Salmonella Typhi: from a Human Pathogen to a Vaccine Vector
نویسندگان
چکیده
منابع مشابه
A mouse model for the human pathogen Salmonella typhi.
Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoietic stem and progenitor cells are able to support S. Typhi replication and pers...
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Salmonella Typhi is an exclusive human pathogen that causes typhoid fever. Typhoid toxin is a S. Typhi virulence factor that can reproduce most of the typhoid fever symptoms in experimental animals. Toxicity depends on toxin binding to terminally sialylated glycans on surface glycoproteins. Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic...
متن کاملEvaluation in volunteers of a candidate live oral attenuated Salmonella typhi vector vaccine.
Candidate vector vaccine strain CVD 906 (aroC- and aroD- derivative of virulent Salmonella typhi strain ISP1820) was evaluated in phase 1 clinical trials. The first nine volunteers ingested a single dose of 5 x 10(7) CVD 906 bacilli. At this dose CVD 906 stimulates remarkable systemic and mucosal immune responses, inasmuch as 89% of volunteers developed marked serum antibody levels to S. typhi ...
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It seems that rapid destruction of gram negative bacteria by antibiotics contributes to the clinical deterioration of some patients with gram negative infections. Antibiotics increase the concentration of lipopolysaccharide (LPS) in blood and cerebrospinal fluids. Released LPS can activate blood cells to produce tumor necrosis factor-alpha (TNF-a) and other cytokines. TNF-a appears to be a ...
متن کاملH-NS and genomic bridge building: lessons from the human pathogen Salmonella Typhi.
The H-NS protein has emerged as one of the leading causes of transcriptional repression in Gram-negative bacteria. In a paper published in this issue, De la Cruz and colleagues shed new light on the role of DNA curvature in the repressive mechanism, using a porin gene promoter from the human pathogen Salmonella Typhi as their experimental system (De la Cruz et al., 2009). Their data help to dee...
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ژورنال
عنوان ژورنال: Cellular & Molecular Immunology
سال: 2008
ISSN: 1672-7681,2042-0226
DOI: 10.1038/cmi.2008.11